Figure 1(PBS):This Picture of PBS Shows Clumps of Many Platelets by Thrombocytosis and Two Segmented Neutrophils.
Figure 2(BM):The Marrow Smear in Normocellular, with a Marked Prolufration of Megakaryocytes, which are Large to Giant, Have Abundant, Mature and Granular Cytoplasm, Deeply LibulTed or Hyperlobulated Nuclei and Form Liose Clusters.Naked Nuclei of Negakaryocytes are Marked by Green arrows.
Figure 3 (BM):In This Picture of Marrow Smear with two Giant Megakaryocytes, the Upper Cell has Typical Hyperlobulated (Stag-Horn Shape)Nuclei and Some Nuclei Fragments in the Cytoplasm.
Figure 4:Schematic Representstion of the CALR Protein.
4A:The Scheme Shows Domains of the Wild -Tyoe CALR Prot(N,P,C ;SP-Signal Peptide)
4B:CALR Mutations Involve Insertions or Deletions in Exone 9,Leading to the Creation of a new C-End of the Protein (Red arrow).Due to the Loss of KDEL Sequence ,the Protein is no longer Kept in the Endoplasmic Reticulin.
5:This Figure Shows PCR Amplification Products. The First Band Shows a CALR-Negative Sample (Lane -2,Yellow arrow)Whereas the Second and Third Sample are CALR-Positive.One Mutation us of Type 1-Deletion of 52bp (Lane 3,Red arrow A)and One Mutation is of Type2-Insertion of 5 bp (Lane 4 , Red arrow B).The Green arrow (Lane 5)Indicates No Template Control(NTC).A DNA Size Marker Was Applied (Lane 1,Black arrow).
Figure 6(BM):Essential Thrombocythemia. 50 Year Old Man with Thrombocytosis 587000. Normocellular Hematopoiesis without Fibrosis.
Figure 7:The BM Smear Shows Increased Number of Megakaryocytes in Otherwise Normocellular Hematopoiesis with an Adequate Appearance of the Granulocyte and Erythroid Series.
Figure 8:Megakaryocytes aren Forming Loose Clusters.The Cells are Normally Sized or Enlarged, Mature Appearing ,Often with Hyperlobated Nuclei.
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