Alzheimer’s disease (AD) falls the category of a mental disease. I can guarantee you, this condition expands far beyond the central nervous system. It intertwines strongly with genetics, the endocrine and cardiovascular systems. However even more so it’s damages the person and their social setting.
AD is a chronic disease. The first signs of AD or dementia are years into the progression of the disease. This is why medicine is often empty handed in solutions.
We see countless studies suggesting insulin resistance may play an causal role in AD. The brain relies on blood glucose but when levels are uncontrolled, we see production of AGEs (advanced glycation end products, which cause irreversible damage to your cell membranes). This is also believed to contribute to the protein misfolding, of tau & alpha-synuclein.
Cardiovascular disease is one of the top 3 killers in the US. But when we think of CV disease, we think of strokes and heart attacks. But long term deprived cerebral vascularization occurring from endothelial dysfunction, atherosclerosis, hyperlipidemia & inflammation leads to cognitive impairment likely due to atrophy of neurons and white matter.
Genetics, the one thing we want to give more credit to for conditions. And I will be the first to tell you, your genes are important but because of *epigenetics* and *epistatic* relationships, genes do NOT tell the whole story but you sure can take control of the storyline. Apolipoprotein E4 is a significant risk factor (key words: risk factor not diagnostic tool or life sentence). ApoE4 leads to poor clearance of LDL particles, leading more of this atherogenic lipoproteins available for oxidation, which contributes to its cerebrovascular cause. But also ApoE4 prevents neurons from repairing or remodeling. Essentially resulting in tau protein production.
I want to bring up this topic because AD is a debilitating disease. It changes humans. I am telling you NOW that you can manage your hormones such as insulin, Leptin, adiponectin which all can have preventive influences on the hormonal, insulinogenic, cardiovascular, cerebrovascular and genetic complements of AD. - 5 hours ago